Interventions for Improving Long COVID-19 Symptomatology: A Systematic Review

Nicola Veronese, Roberta Bonica, Sergio Cotugno, Ottavia Tulone, Michele Camporeale, Lee Smith, Mike Trott, Olivier Bruyere, Luigi Mirarchi, Giuseppina Rizzo, Davide Fiore Bavaro, Mario Barbagallo, Ligia J Dominguez, Claudia Marotta, Andrea Silenzi, Emanuele Nicastri, Annalisa Saracino, Francesco Di Gennaro. Viruses. 2022 Aug 24;14(9):1863.

ReviewHumansWith luteolin, with olfactory rehabilitation (in the included trial)

This study tested palmitoylethanolamide together with luteolin, with olfactory rehabilitation (in the included trial). Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.

Design

Review

Subjects

Two intervention studies included from 1638 screened records

Dose used in the study

Not stated in the abstract

Duration

Search through 15 May 2022

What was measured

What treatments help long COVID symptoms lasting at least 12 weeks: a systematic review of randomised or clinical trials, including palmitoylethanolamide for smell loss.

What the authors reported

Only two intervention studies met the criteria. One RCT reported greater improvement in post-COVID olfactory dysfunction with olfactory rehabilitation plus oral palmitoylethanolamide and luteolin. The other reported a positive effect of aromatherapy on fatigue in women. The authors say more intervention studies are needed.

Limits of this study

A systematic review with only two included studies and no pooled analysis. The authors declare no conflict of interest.

Source

PubMed 36146672 · doi:10.3390/v14091863

Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.