N-palmitoylethanolamide attenuates negative emotions induced by morphine withdrawal in mice
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Mice given morphine then a 10-day withdrawal period
- Dose used in the study
- Not stated in the abstract
- Duration
- 10-day withdrawal period
- What was measured
- Anxiety- and depression-like behaviours after morphine withdrawal, and monoamine neurotransmitter (serotonin, noradrenaline, dopamine) levels in the hippocampus and prefrontal cortex
What the authors reported
Palmitoylethanolamide reduced anxiety- and depression-like behaviours linked to morphine withdrawal and reduced serotonin, noradrenaline and dopamine levels in the hippocampus and prefrontal cortex.
Limits of this study
A mouse model of morphine withdrawal; it cannot show effect in people. Funding and conflicts not stated in the abstract.
Source
PubMed 39154843 · doi:10.1016/j.neulet.2024.137944
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.