Modulation of type 1 cannabinoid receptor activity by cannabinoid by-products from Cannabis sativa and non-cannabis phytomolecules
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Chinese hamster ovary cells expressing human CB1R; male mice for selected compounds
- Dose used in the study
- Ten phytomolecules including palmitoylethanolamide, with or without delta-9-THC; concentrations and doses not stated in the abstract
- Duration
- Not stated in the abstract
- What was measured
- CB1R binding, inhibition of forskolin-stimulated cAMP and beta-arrestin2 recruitment in cells; catalepsy, hypothermia and anti-nociception in mice for selected compounds
What the authors reported
The cannabinoids tested showed partial agonist activity at CB1R, and the phytomolecules modulated delta-9-THC-dependent binding and signalling in vitro and in vivo. The abstract does not report PEA-specific results.
Limits of this study
A cell and mouse study; it cannot show effect in people. PEA-specific findings are not given in the abstract. The authors declare no commercial or financial conflicts.
Source
PubMed 36091813 · doi:10.3389/fphar.2022.956030
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.