PPARα agonist relieves spinal cord injury in rats by activating Nrf2/HO-1 via the Raf-1/MEK/ERK pathway
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Rats with spinal cord injury induced by a modified Allen's method; numbers not stated in the abstract
- Dose used in the study
- Palmitoylethanolamide; dose and route not stated in the abstract
- Duration
- Assessed at 1, 3 and 7 days after injury
- What was measured
- BBB locomotor scores; spinal cord histology; reactive oxygen species, acrylamide and MnSOD; NF-kappa-B, Bcl-2, BAX, PI3K/Akt, Nrf2, HO-1, TRX-1 and Raf-1/MEK/ERK proteins
What the authors reported
PEA reduced spinal cord injury in rats, inhibited inflammatory responses, reduced oxidative stress and apoptosis, and improved motor function recovery. It activated MEK and ERK phosphorylation, moved Nrf2 into the nucleus and raised HO-1 and TRX-1.
Limits of this study
A rat model of spinal cord injury; it cannot show effect in people. Dose, route and animal numbers are not in the abstract. The authors declare no conflicts of interest.
Source
PubMed 34799468 · doi:10.18632/aging.203699
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.