Serum lipid analysis and isotopic enrichment is suggestive of greater lipogenesis in young long-term cannabis users: A secondary analysis of a case-control study
Observational studyHumans
- Design
- Observational study
- Subjects
- 21 cannabis users and 16 non-users
- Dose used in the study
- Not stated in the abstract; no treatment was given
- Duration
- Not stated in the abstract
- What was measured
- Serum fatty acids, a de novo lipogenesis index, carbon-13 isotope signature of palmitic acid, glucose, pyruvate, lactate, cytokines, 2-AG and palmitoylethanolamide.
What the authors reported
The study found:
- Cannabis users had higher palmitic, palmitoleic and oleic acids, a higher lipogenesis index and a more enriched 13C signature, suggesting more lipogenesis.
- Pyruvate and lactate were lower.
- 2-AG was elevated.
- Inflammatory cytokines did not differ.
- Palmitoylethanolamide was elevated in cannabis users.
Limits of this study
A small exploratory secondary analysis that measured natural palmitoylethanolamide in blood; it did not test PEA as a treatment and diet was not controlled. The authors declare no competing interests.
Source
PubMed 35075659 · doi:10.1002/lipd.12336
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.