Effects of omega-3 supplementation on components of the endocannabinoid system and metabolic and inflammatory responses in adipose and liver of peripartum dairy cows
Controlled trialOther animals
- Design
- Controlled trial
- Subjects
- 28 transition Holstein dairy cows fed saturated fat or encapsulated flaxseed oil
- Dose used in the study
- No palmitoylethanolamide was given; tissue levels were measured after omega-3 (flaxseed oil) supplementation
- Duration
- The transition period around calving
- What was measured
- Endocannabinoid system components, metabolic and inflammatory markers in blood, liver and subcutaneous adipose tissue.
What the authors reported
The trial found:
- Flaxseed oil reduced feed intake by 8.1%, plasma arachidonic acid by 44.2% and anandamide by 49.7%.
- Adipose PEA was 61.5% lower in the flaxseed group (P = 0.02).
- Liver 2-AG tended to be higher and liver IL-6 mRNA was 1.5-fold lower.
- Omega-3 partly modulates endocannabinoid activation, the authors say.
Limits of this study
A dairy cow feeding study; PEA was measured, not given. Cows are not a model for people or companion animals. The authors declare no competing interests.
Source
PubMed 36183098 · doi:10.1186/s40104-022-00761-9
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.