Ultramicronized Palmitoylethanolamide Inhibits NLRP3 Inflammasome Expression and Pro-Inflammatory Response Activated by SARS-CoV-2 Spike Protein in Cultured Murine Alveolar Macrophages
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Primary cultures of murine alveolar macrophages exposed to SARS-CoV-2 spike protein
- Dose used in the study
- Ultramicronised PEA at increasing concentrations in cell culture, alone or with the PPAR-alpha antagonist MK886
- Duration
- Not stated in the abstract
- What was measured
- Inflammatory markers (TLR4, p-p38 MAPK, NF-kappa-B), NLRP3 inflammasome activation (NLRP3, Caspase-1), cytokine release (IL-6, IL-1beta, TNF-alpha) and ACE-2 expression after spike protein challenge
What the authors reported
Spike protein exposure increased all measured inflammatory markers and ACE-2 expression in a concentration-dependent way. Ultramicronised PEA reduced these increases in a concentration-dependent way, including NLRP3 inflammasome signalling, and this effect worked through PPAR-alpha.
Limits of this study
A cell-culture study using murine macrophages; it cannot show effect in people or animals. The authors declare no conflicts of interest.
Source
PubMed 34564408 · doi:10.3390/metabo11090592
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.