Palmitoylethanolamide Mitigates Paclitaxel Toxicity in Primary Dorsal Root Ganglion Neurons
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Primary dorsal root ganglion (DRG) neurons isolated from 6- to 8-week-old Wistar rats
- Dose used in the study
- Paclitaxel (0.01-10 micromolar) or palmitoylethanolamide (0.1-10 micromolar) alone or combined, applied to cultured neurons
- Duration
- Assessed at 24, 48 and 72 hours after treatment
- What was measured
- Cell viability (MTT assay), neurite length and soma size of dorsal root ganglion neurons
What the authors reported
This laboratory study found:
- Paclitaxel reduced cell viability at 72 hours and reduced neurite length at nearly all time points while increasing soma size.
- Adding palmitoylethanolamide reduced these paclitaxel effects.
- Palmitoylethanolamide alone increased neuron viability at all concentrations tested, improved neurite outgrowth, and decreased soma size at some time points.
Limits of this study
A cell-culture study using isolated rat neurons; it cannot show effect in people or animals with chemotherapy-induced neuropathy. The authors declare no conflict of interest.
Source
PubMed 36551301 · doi:10.3390/biom12121873
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.