Micro Composite Palmitoylethanolamide/Rutin Reduces Vascular Injury through Modulation of the Nrf2/HO-1 and NF-kB Pathways

Fusco R, Siracusa R, Gugliandolo E, Peritore AF, D'Amico R, Cordaro M, Crupi R, Impellizzeri D, Gomiero C, Cuzzocrea S, Di Paola R. Curr Med Chem. 2021;28(30):6287-6302.

Laboratory studyOther animalsWith rutin

This study tested palmitoylethanolamide together with rutin. Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.

Design

Laboratory study

Subjects

Rats with vascular injury induced by complete ligation of the left carotid artery

Dose used in the study

Micro composite PEA/rutin (1:1), 10 mg/kg; administration route not stated in the abstract

Duration

14 days

What was measured

Vessel morphology; cytokines (MCP-1, IL-1beta, IL-6, TNF-alpha); adhesion molecule ICAM-1; oxidative and nitrosative stress markers (nitrotyrosine, PARP, NRF2 pathway).

What the authors reported

PEA/rutin treatment reduced the vascular morphology change caused by carotid ligation, along with MCP-1, ICAM-1, the cytokines IL-1beta, IL-6 and TNF-alpha, and markers of oxidative and nitrosative stress. Fourteen days after ligation, untreated vessels showed altered morphology with inflammatory cell infiltration and reactive oxygen species production.

Limits of this study

A rat model of surgically induced vascular injury; it cannot show effect in people. Funding and conflicts not stated in the abstract.

Source

PubMed 33781184 · doi:10.2174/0929867328666210329120213

Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.