Palmitoylethanolamide and Polydatin combination reduces inflammation and oxidative stress in vascular injury
Laboratory studyOther animalsWith polydatin
This study tested palmitoylethanolamide together with polydatin. Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Laboratory study
- Subjects
- Rats with carotid artery ligation to induce vascular injury (neointimal hyperplasia)
- Dose used in the study
- PEA/polydatin combination 30 mg/kg; route not stated
- Duration
- 14 days
- What was measured
- Vessel structural change, adhesion molecules (ICAM-1, VCAM-1), proinflammatory cytokines (TNF-alpha, IL-1beta), iNOS, PAR, NF-kB and apoptosis markers (BAX, Fas-Ligand).
What the authors reported
PEA/polydatin 30 mg/kg reduced the vascular structural damage caused by carotid ligation, along with adhesion molecule expression (ICAM-1, VCAM-1), the proinflammatory cytokines TNF-alpha and IL-1beta, iNOS, PAR formation, NF-kB activation and apoptosis markers, all of which ligation had raised.
Limits of this study
A rat model of surgically induced vascular injury; it cannot show effect in people. Funding and conflicts not stated in the abstract; the group has used Epitech-linked co-micronised PEA formulations before.
Source
PubMed 28676456 · doi:10.1016/j.phrs.2017.06.014
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.