Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice

F Guida, L Luongo, F Marmo, R Romano, M Iannotta, F Napolitano, C Belardo, I Marabese, A D'Aniello, D De Gregorio, F Rossi, F Piscitelli, R Lattanzi, A de Bartolomeis, A Usiello, V Di Marzo, V de Novellis, S Maione. Mol Brain. 2015;8:47.

Laboratory studyOther animals

Design

Laboratory study

Subjects

Mice with spared nerve injury (SNI) of the sciatic nerve, assessed 30 days after surgery

Dose used in the study

PEA administration; exact dose and route not detailed in the abstract

Duration

Assessed 30 days after nerve injury

What was measured

Mechanical and thermal pain sensitivity, depression-like behaviour, cognitive function, obsessive-compulsive-like activity, and glutamate synapse proteins and amino acid levels in the medial prefrontal cortex.

What the authors reported

PEA treatment reduced pain-related behaviours and depression-like signs in nerve-injured mice and restored glutamate synapse proteins and amino acid release toward normal. Before treatment, the mice had shown mechanical and thermal pain sensitivity, depression-like behaviour, cognitive impairment, obsessive-compulsive-like activity, and altered glutamate synapse proteins in the prefrontal cortex.

Limits of this study

A mouse model of surgically induced nerve injury; it cannot show effect in people with neuropathic pain. Dose and route of PEA are not stated in the abstract. Funding and conflicts not stated in the abstract.

Source

PubMed 26260027 · doi:10.1186/s13041-015-0139-5

Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.