Altered gut microbiota and endocannabinoid system tone in vitamin D deficiency-mediated chronic pain
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Mice on a low vitamin D diet, normal-diet controls, and mice with spared nerve injury; numbers not stated in the abstract
- Dose used in the study
- Palmitoylethanolamide; dose and route not stated in the abstract
- Duration
- Not stated in the abstract
- What was measured
- Gut microbiota composition, tactile allodynia, spinal neuronal excitability, spinal and gut endocannabinoid system markers.
What the authors reported
This laboratory study found:
- PEA counteracted the pain behaviour and spinal changes caused by vitamin D deficiency, and increased Akkermansia, Eubacterium and Enterobacteriaceae versus vehicle.
- Deficiency itself lowered microbial diversity, raised Firmicutes and lowered Verrucomicrobia and Bacteroidetes, and deficient mice showed allodynia, spinal hyperexcitability and altered endocannabinoid markers.
- Nerve injury did not change the microbiota.
Limits of this study
A mouse model; it cannot show effect in people. PEA dose, route and numbers are not in the abstract. Funding and conflicts not stated in the abstract.
Source
PubMed 30953765 · doi:10.1016/j.bbi.2019.04.006
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.