Palmitoylethanolamide (PEA) reduces postoperative adhesions after experimental strabismus surgery in rabbits by suppressing canonical and non-canonical TGFβ signaling through PPARα
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Rabbits after experimental strabismus surgery
- Dose used in the study
- Palmitoylethanolamide, or the NAAA inhibitor F96; doses and route not stated in the abstract
- Duration
- Not stated in the abstract
- What was measured
- Postoperative inflammation, fibroproliferation and scar formation in extraocular muscle; canonical and non-canonical TGF-beta signalling; PPAR-alpha binding to TAK1.
What the authors reported
PEA reduced postoperative inflammation and fibroproliferation and prevented scar formation through PPAR-alpha; blocking PEA breakdown with F96 gave the same result. PPAR-alpha activation suppressed TGF-beta signalling and bound directly to TAK1, preventing its hyperphosphorylation and downstream p38 and JNK activation.
Limits of this study
A rabbit surgical model; it cannot show effect in people. Doses and route are not stated in the abstract. Funding and conflicts not stated in the abstract.
Source
PubMed 33385371 · doi:10.1016/j.bcp.2020.114398
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.