PPARα-Dependent Effects of Palmitoylethanolamide Against Retinal Neovascularization and Fibrosis
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- A rat Muller cell line (rMC-1), a mouse model of oxygen-induced retinopathy (OIR), and very-low-density lipoprotein receptor (VLDLR) knockout mice
- Dose used in the study
- PEA given by intraperitoneal injection or oral administration; exact dose not stated in the abstract
- Duration
- Not stated in the abstract
- What was measured
- Inflammation and profibrotic markers by western blot, and GFAP and PPAR-alpha by RT-PCR and western blot, in retina and Muller cells
What the authors reported
Profibrotic changes were present in OIR and VLDLR-knockout retinas. PEA reduced inflammation, inhibited neovascularization and suppressed profibrotic changes and Muller gliosis in both models, and in rMC-1 cells. PPAR-alpha mRNA and protein rose with PEA treatment, and the effects of PEA were lost in PPAR-alpha knockout OIR mice.
Limits of this study
A cell-line and animal-model study; it cannot show effect in people. The authors declare no financial or proprietary interest.
Source
PubMed 32298438 · doi:10.1167/iovs.61.4.15
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.