Innovative Nanoparticles Enhance N-Palmitoylethanolamide Intraocular Delivery

Carmelo Puglia, Paolo Blasi, Carmine Ostacolo, Eduardo Sommella, Claudio Bucolo, Chiara B M Platania, Giovanni L Romano, Federica Geraci, Filippo Drago, Debora Santonocito, Barbara Albertini, Pietro Campiglia, Giovanni Puglisi, Rosario Pignatello. Front Pharmacol. 2018 Mar 28;9:285.

Laboratory studyOther animalsTopical

Design

Laboratory study

Subjects

Rabbit eyes, ocular pharmacokinetic and tolerability study

Dose used in the study

PEA-loaded nanostructured lipid carriers (PEA-NLC) applied topically, compared with a PEA suspension

Duration

Not stated in the abstract

What was measured

PEA levels in ocular tissues (vitreous, retina) by liquid chromatography-tandem mass spectrometry, and ocular tolerability

What the authors reported

PEA-NLC significantly raised PEA levels in ocular tissues compared with a plain PEA suspension, with vitreous Cmax of 5919±541 pmol/g and retinal Cmax of 315±70 pmol/g. The formulation showed high stability and good ocular tolerability in rabbits.

Limits of this study

A rabbit study of a drug-delivery formulation, not a treatment trial; it cannot show effect on retinal disease in people. Funding and conflicts not stated in the abstract.

Source

PubMed 29643808 · doi:10.3389/fphar.2018.00285

Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.