Ultramicronized N-palmitoylethanolamine associated with analgesics: Effects against persistent pain
ReviewHumansOther animals
- Design
- Review
- Subjects
- Narrative review of preclinical and clinical studies
- Dose used in the study
- Not applicable
- Duration
- Not applicable
- What was measured
- Pharmacokinetic and pharmacodynamic data on ultramicronised palmitoylethanolamide, its use as an add-on to analgesics, and animal data on limiting opioid tolerance
What the authors reported
Micron-size forms have higher oral efficacy than plain powder, cross the gut wall and blood-brain barrier, and can be used as an add-on to analgesics, with animal data showing they limit opioid tolerance.
Limits of this study
Narrative. Two authors received a grant from Epitech, which makes the ultramicronised product the review favours. The claim of superior oral efficacy over plain powder rests on animal data; see the micronised page.
Source
PubMed 38615798 · doi:10.1016/j.pharmthera.2024.108649
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.