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Orofacial Pain Management: An Overview of the Potential Benefits of Palmitoylethanolamide and Other Natural Agents

Santonocito S, Donzella M, Venezia P, Nicolosi G, Mauceri R, Isola G. Pharmaceutics. 2023;15(4):1193.

ReviewHumans

Design
Review
Subjects
Narrative review
Dose used in the study
Not applicable
Duration
Not applicable
What was measured
Whether palmitoylethanolamide can help orofacial pain: burning mouth, oral lichen planus, periodontal disease, temporomandibular disorders and post-operative pain, plus the underlying mechanism literature

What the authors reported

Clinical data on palmitoylethanolamide in orofacial pain are still lacking, the authors say, and they set out the mechanism case for testing it.

Limits of this study

A review that says itself the clinical data are lacking. The two relevant trials on this site are Marini 2012 (jaw joint) and Ottaviani 2019 (burning mouth). Open access, MDPI.

Source

PubMed 37111679 · doi:10.3390/pharmaceutics15041193

Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.