Endocannabinoid and N-acylethanolamide levels in rat brain and spinal cord following systemic dipyrone and paracetamol administration
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Wistar rats; numbers not stated in the abstract
- Dose used in the study
- No palmitoylethanolamide was given; dipyrone 150, 300 or 600 mg/kg or paracetamol 30, 100 or 300 mg/kg by intraperitoneal injection
- Duration
- Nociception tested at 1, 5 and 12 hours after injection
- What was measured
- Tail-flick and hot-plate responses; anandamide, 2-AG, palmitoylethanolamide and oleoylethanolamide in periaqueductal grey, rostral ventromedial medulla and spinal cord by LC-MS/MS.
What the authors reported
This laboratory study found:
- Both drugs were antinociceptive.
- Paracetamol raised 2-AG in the PAG and RVM at 12 hours, but dipyrone did not.
- Both analgesics lowered anandamide in the RVM and spinal cord, with similar decreases in palmitoylethanolamide and oleoylethanolamide in those regions.
- The authors describe the overall pattern of effects as complicated.
Limits of this study
A rat study measuring endogenous levels after common analgesics; no PEA was given and it cannot show effect in people. Funding and conflicts not stated in the abstract.
Source
PubMed 31283890 · doi:10.1139/cjpp-2019-0015
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.