A Combination of α-Lipoic Acid (ALA) and Palmitoylethanolamide (PEA) Blocks Endotoxin-Induced Oxidative Stress and Cytokine Storm: A Possible Intervention for COVID-19
Laboratory studyHumansWith alpha-lipoic acid
This study tested palmitoylethanolamide together with alpha-lipoic acid. Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Laboratory study
- Subjects
- Human lung epithelial cells stimulated with lipopolysaccharide (LPS)
- Dose used in the study
- 50 micromolar alpha-lipoic acid plus 5 micromolar palmitoylethanolamide, applied to cells before or after LPS
- Duration
- Not stated in the abstract
- What was measured
- Reactive oxygen species, nitric oxide and cytokines linked to the COVID-19 cytokine storm in an LPS cell model of acute lung injury.
What the authors reported
The combination reduced reactive oxygen species and nitric oxide and modulated the main cytokines, whether given before or after LPS. The largest effect was seen when it was given after LPS.
Limits of this study
A cell-culture study; it cannot show any effect in people with COVID-19 or any other illness. Funding and conflicts not stated in the abstract.
Source
PubMed 34405764 · doi:10.1080/19390211.2021.1966152
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.